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Fig. 6 | BMC Systems Biology

Fig. 6

From: Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology

Fig. 6

Impact of phenytoin on single oral dose estradiol kinetics in women. Estradiol venous blood concentrations were simulated for the 1495-person virtual population following a 0.5 mg, b 1 mg, or c 2 mg oral estradiol. PXR occupancy, PXR target-gene mRNA and protein levels were set to reflect concomitant exposure to 0μM, 40μM or 80μM phenytoin, as indicated. A representative concentration-time plot is shown in the left panel, with AUC and Cmax (mean ± s.d.) presented in the middle and right panels, respectively. Statistical significance was assessed using a two-way ANOVA with Sidak’s multiple comparison test. *** = p < 0.001 compared to 0μM phenytoin

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