Fig. 2

Prediction of estradiol binding to plasma proteins. a Steady-state binding of 25 nM estradiol to albumin and steroid hormone binding globulin (SHBG) were simulated within the PBPK model and compared to clinical data and the prediction of Plowchalk and Teeguarden. b Steady-state binding of 25 nM estradiol to albumin and SHBG were simulated for the PBPK model and compared to prediction from the PBPK-LiverODE and PBPK-GSMN models, and experimental data of Sodergard et al. [43]