Table 3 Top 20 predicted disease genes for obesity, prostate cancer and lung cancer
From: Gene gravity-like algorithm for disease gene prediction based on phenotype-specific network
Obesity | Prostate cancer | Lung cancer | ||||||
|---|---|---|---|---|---|---|---|---|
rank | Gene symbol | Class | rank | Gene symbol | Class | rank | Gene symbol | Class |
1 | ADRB2 | √ | 1 | AR | √ | 1 | EGFR | √ |
2 | PPARG | √ | 2 | PTEN | √ | 2 | ERBB2 | √ |
3 | ADRB3 | √ | 3 | ZFHX3 | √ | 3 | BRAF | √ |
4 | MC4R | √ | 4 | BRCA2 | √ | 4 | KRAS | √ |
5 | ENPP1 | √ | 5 | CDH1 | √ | 5 | CASP8 | √ |
6 | GHRL | √ | 6 | CHEK2 | √ | 6 | PIK3CA | √ |
7 | UCP3 | √ | 7 | HIP1 | √ | 7 | PARK2 | √ |
8 | NR0B2 | √ | 8 | MXI1 | √ | 8 | FASLG | √ |
9 | POMC | √ | 9 | MAD1L1 | √ | 9 | MAP3K8 | √ |
10 | CARTPT | √ | 10 | KLF6 | √ | 10 | RASSF1 | √ |
11 | UCP1 | √ | 11 | MSR1 | √ | 11 | IRF1 | √ |
12 | PPARGC1B | √ | 12 | CD82 | √ | 12 | ERCC6 | √ |
13 | AGRP | √ | 13 | TP53 | * | 13 | SLC22A18 | √ |
14 | SDC3 | √ | 14 | BRCA1 | * | 14 | PPP2R1B | √ |
15 | HNF4A | ~ | 15 | MAD2L1 | ~ | 15 | DLEC1 | √ |
16 | ESR1 | * | 16 | EGFR | * | 16 | HRAS | * |
17 | SIM1 | √ | 17 | SIN3A | * | 17 | AKT1 | * |
18 | MC3R | * | 18 | MAX | * | 18 | TP53 | * |
19 | MC1R | * | 19 | CTNNB1 | ~ | 19 | GRB2 | ~ |
20 | LEP | * | 20 | MYC | * | 20 | TGFBR2 | * |