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Fig. 2 | BMC Systems Biology

Fig. 2

From: Gene gravity-like algorithm for disease gene prediction based on phenotype-specific network

Fig. 2

An example for the construction of the phenotype-specific network for phenotype P i Assume that P 1, P 2 are phenotypes similar to given phenotype P i with similarity score s i1 and s i2 respectively. {e, d, f} is the disease gene set of P 1, and {f, g, h} is the disease gene set of P 2. The phenotype-specific network is constructed by mapping phenotype similarity information into the original PPI network, in which links between genes of the same phenotype are created while corresponding phenotype similarity score is added to the original weight. The dot line denotes the new generated edge

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