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Table 1 Hypothesis deletions for enhancing naringenin production in C. glutamicum and corresponding sorting criteria

From: OptPipe - a pipeline for optimizing metabolic engineering targets

Strain

Growth rate

min Nar

max Nar

Distance to WT

p-value

q-value

Method

 

(h −1)

(mmol/gDCW/h)

(mmol/gDCW/h)

(mmol/gDCW/h)

   

wild type

0.50

0

0

    

Δ ackA Δ metY

0.32

0

0.50

400

0.0742

0.0779

OptKnock a

Δ pta Δ ilvA_ile

0.20

0

0.50

404

0.2432

0.1197

 

Δ pta Δ metY

0.32

0

0.50

400

0.2342

0.1197

 

Δ ackA Δ ilvA_ile

0.20

0

0.50

404

0.4139

0.1285

 

Δ ackA Δ metY

0.32

0

0.50

400

0.3656

0.1285

 

Δ sdhCAB Δ ddh

0.21

0

0.50

545

0.5443

0.1285

OptKnock

Δ mdh Δ pyc

0.23

0

0.49

39

0.5377

0.1285

screening

Δ pyc Δ zwf

0.13

0

0.50

565

0.8300

0.1285

 

Δ pyc Δ opcA

0.13

0

0.50

565

0.8580

0.1285

 

Δ pyc Δ gnd

0.13

0

0.50

565

0.8784

0.1285

 

Δ pyc Δ rpe

0.16

0

0.50

441

0.7986

0.1285

 

Δ pyc Δ tkt_1

0.15

0

0.50

532

0.8553

0.1285

 

Δ pyc Δ tal

0.15

0

0.50

532

0.8940

0.1285

 

Δ pyc Δ tkt_2

0.17

0

0.50

413

0.8340

0.1285

 

Δ pyc Δ pmmB

0.19

0

0.17

47

0.7249

0.1285

 
  1. aOptKnock result corresponding to the (single) obtained solution