Construction and analysis of gene-gene dynamics influence networks based on a Boolean model

BMC Systems Biology

Table 3 Example of gene pairs which are molecularly non-interacting but dynamically influential (MNDI)

Network	Gene pairs	Sub-graph	μ(v _i, v _j)	l(v _i, v _j)
AMRN	EMF1, AG	EMF1→ TFL1⊣ AG	0.146	2
AMRN	TFL1, AP1	TFL1⊣ LFY→ AP1	0.0125	2
ABAN	ABA, S1P	ABA→ SphK→ S1P	0.498	2
ABAN	ABA, NIA12	ABA→ RCN1→ NIA12	0.498	2
HSN	CSK, BCR	CSK⊣ LYN→ BCR	0.503	2
HSN	GHR, IGF1R	GHR→ IGF1→ IGF1R	0.382	2

Source and target genes are represented by orange- and green-colored nodes, respectively. Sub-graph field means the shortest path with respect to the gene pair in the GMI network. Arrow-headed (→) and bar-headed (⊣) lines indicate activating (positive) and inhibitory (negative) interactions, respectively

ISSN: 1752-0509