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Table 2 Number of PTM sites associated with drug binding sites

From: Investigation and identification of functional post-translational modification sites associated with drug binding and protein-protein interactions

PTM Instances

Number of PTM sites located on drug contact sites

Number of PTM sites within 12 Å distance of drug contact sites

Phosphorylation

400

1032

Ubiquitylation

164

331

Acetylation

113

296

Pyridoxal phosphate

84

103

N-linked Glycosylation

82

375

O-linked Glycosylation

51

50

S-nitrosylation

38

47

Methylation

25

92

Disulfide bond

18

34

FAD

17

0

Gamma-carboxyglutamic acid

17

32

Proteolytic Cleavage

17

68

C-linked Glycosylation

15

23

N6-carboxylysine

15

12

Carboxylation

12

30

Nucleotide-binding

8

5

Glutathionylation

6

0

Myristoylation

6

10

N6-succinyllysine

6

21

Palmitoylation

6

26

Dephosphorylation

5

5

Oxidation

5

12

FMN

4

0

Prenylation

4

3

Thioether bond

4

19

TPQ

4

0

Deamidation

3

0

Dehydroxylation

3

0

Glycation

3

0

Isopeptide bond

3

0

Neddylation

3

0

Pyruvate

3

0

Sumoylation

3

47

Tryptophylquinone

3

0

ADP-ribosylation

2

3

Biotin

2

0

Deacetylation

2

2

Hydroxylation

2

13

Lipoprotein

2

0

Nitration

2

10

Phosphopantetheine

2

0

Pyrrolidone carboxylic acid

2

21

Tryptophyl-tyrosyl-methioninium

2

0

Allysine

1

0

Amidation

1

36

Carbamidation

1

0

Chromophore

1

0

Formylation

1

1

Lipoyl

1

0

N6-malonyllysine

1

0

S-linked Glycosylation

1

0

Sulfation

1

3

Transglutamination

1

0

TTQ

1

0

Total

1189

2762