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Fig. 6 | BMC Systems Biology

Fig. 6

From: Investigation on changes of modularity and robustness by edge-removal mutations in signaling networks

Fig. 6

Edge-removal analysis for edgetic drug discovery in T-LGL signaling network. The arrows and bar-headed lines represent positive and negative interactions, respectively. Line thickness is proportional to the inclusion frequency of the interaction in top-K edge sets ranked in a decreasing order of the robustness change among 5000 trials of edge-removal mutations with 1% removal rate. The interaction (JAK → STAT3) was observed 30 times in top-K edge sets (K was chosen to 30). (see Additional file 1: Fig. S18 and S19 for the results of STF and HIV-1 networks)

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