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Table 5 The top 20 identified drug-pathway association pairs on NCI-60 data set to L2,1-iPaD and iPaD methods

From: Identifying drug-pathway association pairs based on L2,1-integrative penalized matrix decomposition

Drug

KEGG pathway

L 2, 1-iPaD

iPaD

Validated?

Hydroxyurea

Neuroactive ligand-receptor interation

0

NAN

No

Rebeccamycin

T cell receptor signaling pathway

4.12E-16

4.65E-10

Yes

Tiazofurin

Cell cycle

8.19E-11

7.54E-07

Yes

Selenazofurin

Cell cycle

1.75E-10

2.78E-07

Yes

Mycophenolic Acid

Cell cycle

2.61E-10

2.52E-06

No

Lucanthone

Tight junction

1.04E-08

4.31E-06

Yes

Tanespimycin

Jak-STAT signaling pathway

9.95E-07

2.67E-04

No

Primaquine

Natural killer cell mediated cytotoxicity

1.14E-06

2.69E-04

No

Aminoglutethi-mide

Primary immunodeficiency

1.30E-06

1.16E-04

No

Geldanamycin

Gap junction

7.89E-06

1.87E-04

No

Diallyl Disulfide

Acute myeloid leukemia

8.13E-06

8.41E-05

No

Carmustine

Cell cycle

8.68E-06

4.58E-04

No

Lomustine

Tight junction

1.06E-05

2.64E-04

Yes

Bleomycin

Focal adhesion

1.17E-05

4.56E-04

No

Vitamin K 3

Metabolism of xenobiotics by cytochrome P450

2.22E-05

2.71E-04

No

Melphalan

T cell receptor signaling pathway

2.64E-05

6.16E-04

Yes

Tegafur

Gap junction

6.73E-05

5.60E-04

No

Chloroquine Phosphate

Tight junction

7.12E-05

8.76E-04

Yes

Aclacinomyci- ns

One carbon pool by folate

1.03E-04

5.41E-04

No

Tamoxifen

Pyrimidine metabolism

1.12E-04

1.92E-03

No

  1. The superior results are in italic type