Reconstructing cancer drug response networks using multitask learning

BMC Systems Biology

Table 3 Recurrent Genes for Breast Cancer, Prostate Cancer and Melanoma

Tumor type	Gene	Potential role
Breast cancer	MED1 [35]	Co-activator with Her2 of estrogen
		receptor (ER) in α-positive tumors.
	HDAC3 [34]	Histone deacetylase involved in the
		oncogenic tumorigenesis of breast
		cancer.
	WEE1 [63]	Inhibition of WEE1 causes increased
		cell death in breast cell lines
	GNAS [36]	GNAS locus identified as a driver in
		20q amplified breast cancer
	CDKN1B [64]	Associated with increased breast
		cancer risks
	APP [65]	Androgen-induced gene that
		promotes proliferation activity of
		breast cancer cells.
Prostate cancer	PTPN6 [66]	Tumoral Prostate Shows Different
		Expression Pattern
	PDGFRB [37]	Blockade of PDGF signaling induced
		apoptosis in metastatic PCa cells.
	TAB2 [67]	Deletion of MAP3K7 at 6q12-22 is
		associated with early PSA recurrence
	SQSTM1 [68]	PCa cell lines have high p62/SQSTM1
		levels required for cell survival
	COPS2 [69]	Alien interacts with the human
		androgen receptor and inhibits
		prostate cancer cell growth
	CTBP1 [38]	Dysregulated expression of CTBP1
		plays an important role in prostate
		cancer progression
Melanoma	TNFRSF10A [70]	In vitro IFN- β and TRAIL/Apo2L
		combination treatment had more
		potent apoptotic effects
	ZFP36 [40]	Loss of TTP represents a key event
		in the establishment of melanomas
	PRKCD [71]	Overexpression in BL6 murine
		melanoma cells inhibits the
		proliferative capacity in vivo
	TLE1 [72]	Diagnostic Immunohistochemical
		Marker for Synovial Sarcoma
	XRCC5 [39]	One of only two DNA repair and
		replication proteins which are
		prognostic for melanoma

ISSN: 1752-0509