Fig. 7
Effect of mutation strength on target gene mRNA expression and Dkk concentration. a: The impact on target gene mRNA expression of the readout cell is computed for different APC-dependent β-catenin degradation rates (k 3). A decrease in the APC-dependent β-catenin degradation rate represents an increase in mutation strength (indicated by the grey inlet). b: β-Catenin steady state concentrations in the mutant cell are computed for different APC-dependent β-catenin degradation rates (k 3). The dashed line indicates the maximum possible β-catenin concentration, which is determined by the synthesis rate (v 1) and APC-independent degradation rate constant (k 2). c: Extracellular Dkk concentration at the location of the mutant cell (cell 11) is computed for different APC-dependent β-catenin degradation rates (k 3). All other parameters, including the diffusion coefficient D, are set to the reference parameter values (Additional file 1: Table S1) in the simulations