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Fig. 3 | BMC Systems Biology

Fig. 3

From: An Integrative multi-lineage model of variation in leukopoiesis and acute myelogenous leukemia

Fig. 3

Parameter space constraints for uni-lineage models using dynamic acceptability criteria. Each circle represents the number of simulations that met the acceptability criteria indicated by the corresponding color-coded label. Overlapping circles demonstrate the region in which simulations met multiple criteria. Circles with straight edges represent an inset of the original circle and has been scaled to show other circles more clearly. a shows the acceptability for neutrophil uni-lineage solutions (n = 177 total acceptable), b shows the acceptability for the lymphocyte uni-lineage solutions (n = 1796 total acceptable), and c shows the acceptability for monocyte uni-lineage solutions (n = 1049 total acceptable). In a and b the parameter space constrained by the dynamical acceptability criteria are shown as an inset to distinguish amongst the constrained parameter sets. The two criteria that were salient in determining final total acceptability are indicated with asterisks. The subscripts on the ‘n’s correspond to the numbered criteria from Table 1

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