Fig. 2

Identifying representative patients using qualitative and quantitative model features. Flowchart of the description of constraining uni-lineage and multi-lineage parameter spaces. After setting parameters from literature, parameters specific to each uni-lineage are sampled along with the parameters that are specific to stem cells. We characterize the simulations from these sampled parameter spaces as acceptable or unacceptable from the dynamic acceptability criteria in Table 1 and constrain the parameter space to reflect acceptable solutions. We re-sampled the constrained parameter space of all three lineages and simulated with the multi-lineage model. The simulations that met the acceptability criteria were used for further analysis