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Fig. 2 | BMC Systems Biology

Fig. 2

From: Multitype Bellman-Harris branching model provides biological predictors of early stages of adult hippocampal neurogenesis

Fig. 2

BrdU labels dividing cells in S-phase. 5’-Bromo-2’-deoxyuridine (BrdU) incorporates into the newly synthesized DNA during cell division and can be detected with specific antibodies. BrdU is injected intraperitoneally and the animal is sacrificed at a given time. The brain is isolated and sectioned sagittally for the best visualization of the dentate gyrus. The representative low-magnification image of the dentate gyrus has granule cells labeled by DAPI (blue) and dividing cells labeled by BrdU (pink) (scale bar=20um). In the high magnification confocal micrographs, NSCs and their progeny, ANPs, express Nestin-GFP (green). In addition, NSCs express GFAP (red), while ANPs do not. BrdU-labeled dividing cells are in pink. Scale bar = 50um

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