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Table 1 Targets action changed by the modulator of MDM2

From: Roles of alternative splicing in modulating transcriptional regulation

Predicted model of action

Counts

Active

Repress

Inverts

Positive

116

Non-sig → + 23

‘-’ → ‘-’ 6

‘-’ → ‘+’ 12

- → Non-sig 70

‘+’ → ‘+’ 0

Negative

102

+ → Non-sig 65

‘-’ → ‘-’ 0

‘+’ → ‘-’ 12

Non-sig → - 18

‘+’ → ‘+’ 7

  1. MDM2 as modulator affect the relationship between GR and its targets. Among all the GR targets, MDM2 plays a positive modulation role in 116 targets and plays a negative role in 102 targets (*positive and negative were indicated by β 3value)