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Table 2 Subcellular location and function classification of targeted drug targets

From: A systematic analysis of FDA-approved anticancer drugs

Subcellular location Family Subfamily Number of targets
Cytoplasm (27)
  Enzyme (23) E3 ligase 1
Epigenetic enzyme 1
Monooxygenases 2
Peptidase 6
Phosphatidyl Inositol Kinases 1
Serine/threonine kinase 5
Threonine/tyrosine-protein kinase 2
Tyrosine kinase 5
Other (4) Other 4
Extracellular space (7)
  Cytokine (1) Cytokine 1
Enzyme (1) Phosphatase 1
Growth factor (4) Growth factor 4
Hormone (1) Hormone 1
Nucleus (23)
  Enzyme (13) Epigenetic enzyme 4
Polymerase 3
Ribonucleotide diphosphate reductase 1
Serine/threonine kinase 3
Tyrosine kinase 2
Receptor(10) Ligand-dependent nuclear receptor 10
Plasma membrane (45)
  Antigen (5) Antigen 5
Enzyme(21) Tyrosine kinase 21
Receptor(17) Transmembrane receptor 12
  G-protein coupled receptor 5
Transporter (1) Transporter 1
Other (1) Other 1