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Table 1 List of variables (in units of g/ cm3)

From: Combination therapy for melanoma with BRAF/MEK inhibitor and immune checkpoint inhibitor: a mathematical model

Notation

Description

H

HMGB-1 concentration

N C

Density of necrotic cancer cells

D

Density of DCs

T 1

Density of activated CD 4+ T cells

T 8

Density of activated CD 8+ T cells

T r

Density of activated Treg cells

M

Density of activated MDSCs

C

Density of cancer cells

I 12

IL-12 concentration

I 2

IL-2 concentration

T β

TGF- β concentration

I 6

IL-6 concentration

I 10

IL-10 concentration

P

PD-1 concentration

L

PD-L1 concentration

Q

PD-1-PD-L1 concentration

A

Anti-PD-1 concentration

B

BRAF/MEK inhibitor concentration