Fig. 4

Cell fate map under different microenvironments. The values of the extrinsic signals of the CD4+ T regulatory network were fixed according to different polarizing microenvironments as listed in Table 1, and the resulting attractors were transiently perturbed for one time step. Nodes correspond to cell types, node size is proportional to the number of configurations in a basin of attraction. Edges represent transitions from one cell type to another, their width represents the number of times the transition occurred, self-loops correspond to perturbations in which the network returned to the original cell type. The following microenvironments were studied: pro-Th1, pro-Th1+ Insulin, pro-Th17, pro-Th17 + Insulin, pro-iTreg, pro-iTreg + Insulin, pro-Tr1 and pro-Tr1 + Insulin