Table 5 FVA results showing category change in resistant strains as a function of antibiotic that involve redox cofactor balancing

HEX1

atp[c] + glc-D[c] - > adp[c] + g6p[c] + h[c]

1

7

7

PYK

adp[c] + h[c] + pep[c] - > atp[c] + pyr[c]

7

1

1

AKGDH

akg[c] + coa[c] + nad[c] - > co2[c] + nadh[c] + succoa[c]

1

7

1^a

MDH

mal-L[c] + nad[c] < = > h[c] + nadh[c] + oaa[c]

1

7

1^a

FUM

fum[c] + h2o[c] < = > mal-L[c]

1

7

1^a

SUCOAS

atp[c] + coa[c] + succ[c] < = > adp[c] + pi[c] + succoa[c]

4

7

4^a

ACKr

ac[c] + atp[c] < = > actp[c] + adp[c]

7

4

4

PFL

coa[c] + pyr[c] - > accoa[c] + for[c]

7

1

7^b

PTAr

accoa[c] + pi[c] < = > actp[c] + coa[c]

7

1

1

GLCt2

glc-D[e] + h[e] - > h[c] + glc-D[c]

1

7

7

ACt2r

ac[e] + h[e] < = > ac[c] + h[c]

7

4

4

FORti

for[c] - > for[e]

7

1

7^b

EX_ac(e)

ac[e] < =>

7

1

1

EX_for(e)

for[e] < =>

7

1

7^b