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Table 8 Parameter values achieved in the calibration to check the robustness of the fed-batch model. The confidence interval on the time where the consumption of secondary metabolites started TCONS, could not be determined due to the stiffness of the solution caused by a sudden consumption of arabitol and ethanol

From: Dynamic genome-scale metabolic modeling of the yeast Pichia pastoris

Parameter

Value

Units

v MAX

2.09 ± 0.46

mmol/gDCW · h

K S

5.55 · 10−2 ± 0.0000004 · 10−2

g/L

v Pyr,B

0

mmol/gDCW · h

v Arab,B

0.42 ± 0.17

mmol/gDCW · h

v Cit,B

0.04 ± 0.00

mmol/gDCW · h

v Pyr,FB

0

mmol/gDCW · h

α B

2.6 · 10−4 ± 0.4 · 10−4

[−]

α FB

2.455 · 10−5 ± 0.003 · 10−5

[−]

m ATP

7.0 ± 1.4

mmol/gDCW · h

T Cons

25.73

H