Table 1 Parameters of the model
From: Dynamic genome-scale metabolic modeling of the yeast Pichia pastoris
Symbol | Name | Units | LB | Initial value | UB |
|---|---|---|---|---|---|
v G,max | Maximum glucose uptake rate | mmol/g DCW ·h | 0 | 2.5 | 10 |
K G | Half saturation constant for glucose uptake | g/L | 0 | 10−4 | 10−3 |
v EtOH,B | Ethanol minimum secretion rate (batch) | mmol/g DCW ·h | 0 | 0.5 | 3 |
v Pyr,B | Pyruvate minimum secretion rate (batch) | mmol/g DCW ·h | 0 | 0.1 | 2 |
v Arab,B | Arabitol minimum secretion rate (batch) | mmol/g DCW ·h | 0 | 0.2 | 2 |
v Cit,B | Citrate minimum consumption rate (batch) | mmol/g DCW ·h | 0 | 0 | 2 |
v EtOH,FB | Ethanol minimum consumption rate (fed-batch) | mmol/g DCW ·h | 0 | 0 | 2 |
v Pyr,FB | Pyruvate minimum consumption rate (fed-batch) | mmol/g DCW ·h | 0 | 0 | 2 |
v Arab,FB | Arabitol minimum consumption rate (fed-batch) | mmol/g DCW ·h | 0 | 0 | 2 |
v Cit,FB | Citrate minimum consumption rate (fed-batch) | mmol/g DCW ·h | 0 | 0 | 2 |
α B | Sub-optimal growth coefficient (batch) | [−] | 0 | 0 | 10−3 |
α FB | Sub-optimal growth coefficient (fed-batch) | [−] | 0 | 0 | 10−3 |
m ATP | Non-growth associated ATP | mmol/g DCW ·h | 0 | 2 | 10 |
T Fed | Time when secondary metabolite consumption starts in fed-batch cultures | h | 20 | 25 | 32 |