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Fig. 7 | BMC Systems Biology

Fig. 7

From: A new efficient approach to fit stochastic models on the basis of high-throughput experimental data using a model of IRF7 gene expression as case study

Fig. 7

Time courses in the IRF7 circuit after IFN stimulation. The temporal dynamics of the promoter, mRNA and IRF7 protein dynamics were obtained after stochastic simulations. A representative trajectory that presents a single cell dynamics is given by the red lines. The stochastic simulations were repeated 1000 times using the same initial condition obtaining the histograms that represent the cell population. a Time courses of IFN showing the evolution to a steady state, the same is observed in b for the ISGF3. c IRF7 promoter shows the transition between the two possible states Off/On. d IRF7 mRNA showing a basal expression state and a state of active expression. Bimodality is observed in e for the IRF7 protein, the same bimodal behavior was observed in f for the IRF7 phosphorylated protein, in g for the IRF7 protein dimer, and in h for all forms of the IRF7 protein

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