Fig. 4

Distribution of the transcriptomic alterations that entailed significant rewiring events. Shown is the impact of the considered types of expression changes on interaction partners regarding all individual rewiring events per transition. The types were weighted by their proportional contribution to each event during the pairwise comparison step (left plots) or as the sole contributing cause (right plots). In the latter case, rewiring events that had more than one explanatory transcriptomic cause in a transition were annotated as “mixed”. The types of causes were either normalized by the direction of the rewiring events (upper plots) or by their contributions to individual transitions (lower plots). In the top plots, “+” (blue) means emerging interactions and “-” (green) means vanishing interactions. The bottom three developmental transitions are those towards terminally differentiated cell types found in blood (GMP/N, GMP/M, and CLP/CD4)