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Table 6 Controllability and observability index values for the model of ERK activation controlled via the EGFR pathway

From: A combined model reduction algorithm for controlled biochemical systems

Lumped

Controllability

Observability

Input-output

state-variable

index

index

index

x 1(t)

0.3022

0.0176

0.0053

x 2(t)

0.0201

0.0153

0.0003

x 3(t)

0.0189

0.0009

1.681×10−5

x 4(t)

0.8547

0.2752

0.2352

x 5(t)

0.6194

0.0079

0.0049

x 6(t)

1

1

1

x 7(t)

0.1412

0.1043

0.0147

x 8(t)

0.1378

0.0018

0.0003

x 9(t)

0.1539

0.0164

0.0025

x 10(t)

0.0473

0.0092

0.0004

x 11(t)

0.3312

0.0442

0.0146