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Fig. 3 | BMC Systems Biology

Fig. 3

From: Gene regulatory network underlying the immortalization of epithelial cells

Fig. 3

Temporal sequence and global order of cell–fate attainment pattern under the stochastic Boolean GRN model during epithelial carcinogenesis. a Maximum probability p of attaining each attractor, as a function of time (in iteration steps). The most probable sequence of cell attainment is: epithelial → senescent → mesenchymal stem-like. The error probability used in this case was ξ=0.05. The same patterns were obtained with the 3 different error probabilities tested (data not shown). b Schematic representation of the possible transitions between pairs of attractors. Arrows indicate the directionality of the transitions. Above each arrow a sign (+) or (−) indicates whether the calculated net transition rate between the corresponding attractors is positive or negative. Red arrows represent the globally consistent ordering for the 3 attractors: the order of the attractors in which all individual transition has a positive net rate, resulting in a global probability flow across the EL. c Schematic representation of the time–ordered phenotype transitions along the epigenetic landscape, showing the in–between attractor barrier highs in the landscape

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