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Fig. 4 | BMC Systems Biology

Fig. 4

From: Understanding key features of bacterial restriction-modification systems through quantitative modeling

Fig. 4

a Dynamics of R and M expression. R and M expression upon the system entry in a naïve bacterial host (0 min corresponds to the system entry). The shaded area corresponds to the difference of the surface areas below M (dashed curve) and R (solid curve) expression curves for the first 10 min post-system entry; the area presents a measure of the delay between M and R expression. The dash-dot line corresponds to the maximal slope of the sigmoidal R expression curve, measuring the transition velocity from OFF to ON state. b Steady-state and its stability. The steady-state (indicated by Ceq) is obtained as an intersection of the transcription activity (the solid black line), and the dash-dot line whose slope is determined by the transcript decay and the protein translation rate (Eq. (1.33)). The stability of the steady-state is related with the difference of the dash-dot line slope, and the slope of the transcription activity (the dotted line in the figure) at the point of their intersection Ceq (Eq. (1.34))

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