Fig. 3
From: How time delay and network design shape response patterns in biochemical negative feedback systems
Simulation and response analysis of the p53 model. a Simulation of the p53 model (3) with fitted parameters from Table S1 (see Additional file 1), dots – experimental data from [30], Fig. S6 therein. b Dependence between the stimulus value I and τ m for the p53 model (3) with fitted parameters from Table S1 (see Additional file 1) without and with synthetically activated auto-inhibitory feedback F(C) (with ν=2, κ=1.23 and ν=3, κ=1.73). Dots designate values of τ m calculated for the fitted value of I=0.23 for the p53 model (3) with and without auto-inhibitory feedback