Fig. 2
From: Properties of Boolean dynamics by node classification using feedback loops in a network
Comparison between groups of NFD and non-NFD genes in signaling networks. a Result in KEGG network with 975 NFD genes and 684 non-NFD genes. The proportions of essential genes in the NFD and the non-NFD groups were 0.204 and 0.401, respectively. The proportions of disease genes in the NFD and the non-NFD groups were 0.190 and 0.319, respectively. The proportions of drug-targets in the NFD and the non-NFD groups were 0.148 and 0.306, respectively. b Result in WANG network with 1706 NFD genes and 4600 non-NFD genes. The proportions of essential genes in the NFD and the non-NFD groups were 0.157 and 0.272, respectively. The proportions of disease genes in the NFD and the non-NFD groups were 0.235 and 0.251, respectively. The proportions of drug-targets in the NFD and the non-NFD groups were 0.161 and 0.183, respectively. In both networks, all the proportions for the NFD group were significantly smaller than those for the non-NFD group (all p-values<10−10)