Fig. 8From: Tailored parameter optimization methods for ordinary differential equation models with steady-state constraintsParameter estimation results for Raf/MEK/ERK signaling in HeLa cells. a Convergence and b computational efficiency of local optimization methods for the model with the negative feedback loop (H1). c Best fit of the model with the negative feedback loop (H1) to data for three different treatment conditions. pMEK and pERK signals are rescaled with the respective maximum activity and the light gray area indicates 2- σ interval of the measurement noiseBack to article page