TFs | Gse16011 | Rembrandt | Tiantan | TCGA mRNA | Reported functional remarks | ||||
---|---|---|---|---|---|---|---|---|---|
HR | p-value | HR | p-value | HR | p-value | HR | p-value | Â | |
ZNF423 | 0.188 | 4.81E-15 | 0.769 | 4.91E-09 | 0.4719 | 0.0014 | 0.627 | 5.46E-18 | Overexpression of ZNF423 helps growth inhibition and differentiation. Neuroblastomas with low levels of ZNF423 show extremely poor outcome. [45, 46] |
AHR | 1.1818 | 0.001642 | 1.2669 | 6.45E-26 | 1.5729 | 1.68E-06 | 1.616 | 9.27E-16 | AHR leads proliferation of Medulloblastoma cell. The pathway associated with AHR is active in human brain tumours with malignant progression and poor survival. [47–49] |
NFIL3 | 1.394 | 1.20E-05 | 1.3529 | 5.31E-12 | 2.7649 | 2.18E-08 | 2.093 | 1.86E-15 | NFIL3 is found to be overexpressed in different cancer types [50]. |