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Table 2 Hazard ratios of three TFs in four datasets (GSE16011, Rembrandt, Tiantan, TCGA mRNA datasets)

From: A novel integrated gene coexpression analysis approach reveals a prognostic three-transcription-factor signature for glioma molecular subtypes

TFs

Gse16011

Rembrandt

Tiantan

TCGA mRNA

Reported functional remarks

HR

p-value

HR

p-value

HR

p-value

HR

p-value

 

ZNF423

0.188

4.81E-15

0.769

4.91E-09

0.4719

0.0014

0.627

5.46E-18

Overexpression of ZNF423 helps growth inhibition and differentiation. Neuroblastomas with low levels of ZNF423 show extremely poor outcome. [45, 46]

AHR

1.1818

0.001642

1.2669

6.45E-26

1.5729

1.68E-06

1.616

9.27E-16

AHR leads proliferation of Medulloblastoma cell. The pathway associated with AHR is active in human brain tumours with malignant progression and poor survival. [47–49]

NFIL3

1.394

1.20E-05

1.3529

5.31E-12

2.7649

2.18E-08

2.093

1.86E-15

NFIL3 is found to be overexpressed in different cancer types [50].