Leveraging syntactic and semantic graph kernels to extract pharmacokinetic drug drug interactions from biomedical literature

Table 8 Semantic class description for literature of PK DDI

Semantic class	Definition	Example
Drug	Drugs, metabolites	quinidine
Enzyme	CYP450 enzymes	CYP1A2
PK parameter	PK Parameters	AUC
Number	Dose, sample size, values of PK parameters	40–70 %
Mechanism	Trigger words related to DDI mechanisms	stimulate
Change	Change of PK parameters	decrease
Degree	Severity of PK parameter change	strongly
Negation	Negative expression	negligible

ISSN: 1752-0509