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Fig. 3 | BMC Systems Biology

Fig. 3

From: Digitalization of a non-irradiated acute myeloid leukemia model

Fig. 3

Major factor of HSC loss validated by cell cycle and apoptosis analyses of HSCs in leukemic BM. a Computational decomposition of the HSC dynamics on the relevant processes. Cell expansion (Expn, red), differentiation (Diff, green) and death (Death, blue). b Flow plots (left panel) and histogram (right panel) show the apoptosis frequency of HSCs (LKS+) in leukemic BM [11]. c Flow plots (left panel) and histograms (right panel) show the cell cycle status of HSCs in leukemic BM. Data are represented as the mean ± SEM (n = 12; 3 independent experiments); * p < 0.05 [11]

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