Fig. 2
From: Digitalization of a non-irradiated acute myeloid leukemia model
Cell kinetics simulations of the model with the optimized parameters. (a–c). Computational dynamics of the normal and leukemic cells in PB (a), spleen (b), and BM (c) during leukemia development. These results were generated by the optimized parameters. Exp, Experimental data; Sim, Simulation results; d 1,2 , Model fitness degree (d1- leukemic, d2- normal).; s 1,2 , Sample standard deviation (s 1 - leukemic, s 2 - normal). (d–e). Computational dynamics of HSCs (D) and HPCs (E) with the optimized parameters