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Table 2 Top 20 metabolites that are significantly associated with cognitive decline in AD

From: Towards understanding brain-gut-microbiome connections in Alzheimer’s disease

Metabolite

Enrichment

P value

Literature

 

fold

  

d-proline

28.7

1.50E-39

[26]

1,2,3-propanetricarboxylic acid

19.1

8.45E-39

 

5-aminopentanoic acid

12.1

1.80E-37

 

chenodeoxycholic acid

8.5

6.29E-36

[27]

glycine conjugate

   

cadaverine

7.66

2.42E-35

[28]

benzoyl-coa

7.66

2.42E-35

 

diaminopimelic acid

5.9

1.45E-33

 

putrescine

4.9

5.85E-32

[28]

trehalose

4.7

1.49E-31

 

succinic acid

4.6

2.37E-31

[23]

5-methylthioribulose 1-phosphate

4.4

6.05E-31

 

pyrrolidine

4.2

2.49E-30

[32]

citramalic acid

4.0

6.42E-30

 

trans-ferulic acid

3.8

4.30E-29

[2931]

mannitol

3.5

2.91E-28

[22]

4-hydroxybenzoic acid (DOPAC)

3.6

2.91E-28

[24]

d-glutamic acid

3.4

7.60E-28

[35]

melibiose

3.3

1.99E-27

 

5alpha-cholestanol

3.3

3.24E-27

[33, 34]

1-butanol

3.0

9.63E-26

 
  1. The three known metabolites (mannitol, succinic acid, and DOPAC) are highlighted