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Fig. 6 | BMC Systems Biology

Fig. 6

From: Signaling cascades transmit information downstream and upstream but unlikely simultaneously

Fig. 6

We consider the 5 signaling regimes corresponding to motifs of Fig. 5, as well as associated parameter restrictions characterizing each of them (see details in Discussion). Then, each panel displays the probabilities of a given signaling regime in function of the considered parameter restrictions. Consistently, the probability to get a given signaling regime is maximized by choosing the parameter restrictions characterizing it, and this maximum is significantly higher than the probability obtained from a log-uniform distribution of biochemical parameters without any restriction (cf. first bar of the histogram, NR)

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