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Fig. 3 | BMC Systems Biology

Fig. 3

From: A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms

Fig. 3

Influence of Wip1 gene silencing on cellular response to DNA damage. a Immunoblots of Wip1, active p53, Chk2 and Hdm2 (Mdm2 for mouse) for control and time points 2, 8 and 24 h after exposure to 10 Gy of IR. Experiments were performed for Ctr-RNAi and Wip-RNAi cells. be: Results of stochastic simulations on 1000 cells irradiated with dose of 10 Gy show the levels of various proteins. Solid line stays for median values, dashed for 1st and 3rd quartile, while dashed black lines for time points when experimental data were gathered

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