Fig. 1

Detailed schematic of the ATM/p53/NF κB pathway model. Active and inactive states of proteins and transcripts (mRNA) are presented. The model distinguishes three compartments: the extracellular matrix, the cytoplasm and the nucleus. There are four main modules of the model: p53 (black), NF- κB (gray), ATM (green) and Wip1 (blue). Dotted lines with arrow-heads stand for positive regulation between components, solid lines for transitions between states of the components, crossed circles for degradation of the protein or transcript, and “P” for phosphorylated form of the protein; “a” for ATM stands for fully active form of this kinase