From: Metabolic host responses to malarial infection during the intraerythrocytic developmental cycle
Metabolite | C t=0 h | ΔCtrt=48 h | ΔInft=48 h | ΔPf Inf | Secretion(+)/Uptake(−) | |
mM | mM | mM | mM | RBC | Pf | |
Glucose | 1.11 10+1 | −5.07 10−1 | −9.97 10+0 | −9.5 10+0 | – – – | – – – – |
Myo-Inositol | 1.94 10−1 | −7.29 10−2 | −7.28 10−2 | 8.7 10−5 | – – | – – |
Hypoxanthine | 1.00 10−1 | −1.87 10−2 | −8.09 10−2 | −6.2 10−2 | – – | – – – |
Choline | 2.15 10−2 | 4.05 10−3 | −1.47 10−3 | −5.5 10−3 | + | – |
Nicotinamide | 8.19 10−3 | 0.00 10+0 | −4.95 10−4 | −5.0 10−4 | ○ | – |
p-aminobenzoate | 7.29 10−3 | 0.00 10+0 | 0.00 10+0 | 0.0 10+0 | ○ | ○ |
Pyridoxine | 4.86 10−3 | −2.73 10−3 | −2.73 10−3 | 0.0 10+0 | – | – |
Thiamine | 2.96 10−3 | 2.18 10−3 | 1.99 10−3 | −1.9 10−4 | + | + |
Riboflavin | 5.31 10−4 | 0.00 10+0 | −9.35 10−5 | −9.3 10−5 | ○ | – |
Pantothenate | 5.25 10−4 | 0.00 10+0 | −1.25 10−4 | −1.2 10−4 | ○ | – |
Amino acid | C t=0 h | ΔCtrt=48 h | ΔInft=48 h | ΔPf Inf | Secretion(+)/Uptake(−) | |
mM | mM | mM | mM | RBC | Pf | |
Arginine | 1.148 | 0.012 | 0.026 | 1.5 10−2 | + | + |
Asparagine | 0.378 | 0.074 | 0.036 | −3.9 10−2 | + | + |
Aspartate | 0.150 | 0.213 | 0.200 | −1.2 10−2 | ++ | ++ |
Glutamate | 0.136 | 0.848 | 0.726 | −1.2 10−1 | +++ | +++ |
Glutamine | 2.053 | 0.479 | 0.518 | 3.8 10−2 | +++ | +++ |
Histidine | 0.097 | 0.090 | 0.279 | 1.9 10−1 | + | ++ |
(Iso)Leucine | 0.762 | 0.324 | 0.647 | 3.2 10−1 | + | +++ |
Methionine | 0.101 | 0.021 | 0.052 | 3.1 10−2 | + | + |
Phenylalanine | 0.091 | 0.143 | 0.268 | 1.2 10−1 | + | ++ |
Proline | 0.174 | 0.149 | 0.280 | 1.3 10−1 | + | ++ |
Serine | 0.285 | 0.149 | 0.210 | 6.2 10−2 | + | ++ |
Tryptophan | 0.024 | 0.011 | 0.039 | 2.9 10−2 | + | + |
Tyrosine | 0.110 | 0.106 | 0.140 | 3.4 10−2 | + | ++ |
Valine | 0.171 | 0.191 | 0.491 | 3.0 10−1 | ++ | ++ |