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Fig. 7 | BMC Systems Biology

Fig. 7

From: Metabolic host responses to malarial infection during the intraerythrocytic developmental cycle

Fig. 7

Flux ratios for reaction in the glycolysis pathways of human red blood cells. a The ratios of reaction fluxes in cocultured to those in normal red blood cells (RBCs). b Time-dependent ratios of reaction fluxes in infected RBCs to those in normal RBCs and time-dependent ATP transport from Plasmodium falciparum to its host RBC. ATP transport flux was expressed as mmol/(h∙1012 RBC). cRBCs, uninfected RBCs cocultured with iRBCs; DPGase, diphosphoglycerate phosphatase; DPGM, diphosphoglycero mutase; ENO, enolase; FBA, fructose bisphosphate aldolase; GAPD, glyceraldehyde-3-phosphate dehydrogenase; HEX, hexokinase; iRBCs, P. falciparum 3D7-infected RBCs in the infected RBC culture; LDH, lactate dehydrogenase; nRBCs, normal RBCs in the uninfected RBC culture; PFK, phosphofructokinase; PGI, glucose-6-phosphate isomerase; PGK, phosphoglycerate kinase; PGM, phosphoglycerate mutase; PYK, pyruvate kinase; TPI, triose-phosphate isomerase

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