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Fig. 5 | BMC Systems Biology

Fig. 5

From: Qualitative dynamics semantics for SBGN process description

Fig. 5

AT 1A R-mediated ERK activation map. This map represents the two main pathways responsible for the AT 1A R-mediated (and more generally 7TMRs receptors-mediated) ERK activation. The AT 1A R receptor activates the (classical) G protein pathway to reach ERK but also the less known β-arrestins pathway. These pathways are tightly regulated by the presence of molecules called the G-protein coupled receptor kinases (GRK2/3 and GRK5/6), which act directly on the phosphorylation of the receptor. This map is represented using the SBGN-PD language. EPNs with bold borders constitute the initial state of the map. Every colored EPN belongs to a story, and each color is assigned to a different story. The story in pink focuses on the receptor HR and comprises seven different physical states of this receptor: unbound, phosphorylated (on either of two sites), bound to β-arrestin 1 or β-arrestin 2. The other stories focus on ERK (in yellow), on protein G (green), on PIP2 (blue), and on PKC (gray)

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