Parameter | Complete model | wo_feedback P70S6K | wo_feedback ERK1/2 | Process |
---|---|---|---|---|
n_p70 | −433.62 % | - | −553.98 % | p70 mediated IRS1 phosphorylation at Ser |
kcat33 | 158.53 % | 159.60 % | 207.34 % | # Mek phosphorylation |
kcat32 | −157.47 % | −158.57 % | −202.56 % | # Raf inactivation |
k7 | 154.53 % | 23.76 % | 183.15 % | # IRS-1 phosphorylation at Tyr |
k_7 | −154.50 % | −23.96 % | −183.05 % | # IRS-1 dephosphorylation at Tyr |
kcat28 | 152.95 % | 65.18 % | 189.32 % | Ras activation |
kcat29 | −152.78 % | −65.23 % | −188.99 % | # Raf activation |
kcat30 | 150.90 % | 62.38 % | 185.97 % | # Raf activation |
k_7p | 140.15 % | 4.82 % | 161.27 % | # IRS-1 dephosphorylation at Ser |
k15 | −135.17 % | - | −155.79 % | # IRS1 phosphorylation by P70S6K |
kcat35 | 79.97 % | 79.91 % | 104.72 % | Erk phosphorylation |
kcat36 | 77.83 % | 79.00 % | 101.60 % | Erk phosphorylation |
k41 | −34.20 % | −16.98 % | −43.11 % | # IRS1-GS and IRS1-SHP2 complex disruption |
kcat39 | −23.10 % | −25.16 % | - | GS inhibition |
Kd_p70 | 20.02 % | - | 26.18 % | p70 mediated IRS1 phosphorylation at Ser |
Vmax | 15.35 % | 19.63 % | 21.95 % | PKC and p70 mediated IRS1 phosphorylation at Ser |
k8 | −13.39 % | −9.24 % | −17.15 % | # IRS-1_PI3-K complex formation (PI3-K activation) |
k_8 | 13.38 % | 9.27 % | 17.04 % | # IRS-1_PI3-K complex dissociation |
n | 6.66 % | 0.11 % | 7.10 % | PKC mediated IRS1 phosphorylation at Ser |
k_21 | −5.65 % | - | −6.50 % | # TSC1-TSC2 T1462_phosphorylation_by_Akt_pT309 |
k9s | 4.74 % | 0.35 % | 5.35 % | # lipids PI(3,4,5)P3 formation |
k9a | −4.71 % | −0.28 % | −5.48 % | # lipids PI(3,4,5)P3 formation |
k7p | −4.01 % | −4.79 % | −5.32 % | # IRS-1 phosphorylation at Ser |
k4p | −2.62 % | −10.56 % | −4.01 % | # Phosphorylated receptor internalization |
k_39 | 2.62 % | 2.10 % | - | GS inactivation |
k_20 | 2.20 % | - | −0.21 % | # p70S6K phosphorylation/dephosphorylation mediated by mTORC1_pS2448 |
kcat24 | −1.71 % | 87.60 % | 17.49 % | Src activation |
kcat31 | −1.70 % | 87.58 % | 17.35 % | # Raf activation |
alpha24 | −1.60 % | 87.59 % | 17.48 % | Src activation |
k_4 | 0.77 % | 2.59 % | 0.88 % | # Free receptor externalization |
k_16 | 0.13 % | −0.07 % | −0.11 % | # AMPK_T172 dephosphorylation mediated by IRS1_pY |
Kd_pkc | 0.11 % | −0.02 % | 0.00 % | PKC mediated IRS1 phosphorylation at Ser |
k12 | 0.10 % | 0.04 % | −0.03 % | # PKC phosphorylation at Threonine |
k6 | 0.08 % | 0.12 % | −0.01 % | # Receptor unbinding and dephosphorylation (inside the cell) |
k_2 | 0.05 % | −0.11 % | −0.17 % | # Receptor binding 2nd insulin molecule |