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Fig. 1 | BMC Systems Biology

Fig. 1

From: A rule-based model of insulin signalling pathway

Fig. 1

The model of insulin signalling pathway. The model of Insulin Signaling Pathway obtained by integrating the PI3K-AKT pathway, the mTOR pathway and the RAS-MAPK pathway, depicted using the Systems Biology Graphical Notation. Coloured nodes resemble the clustering results obtained on simulated profiles (see Fig.  3 ). Coloured lines represent important feedback mechanisms; namely: the red line represents the P70S6K-IRS1 negative feedback loop, the blue line the ERK1/2-GRB2/SOS negative feedback loop

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