Fig. 3

All available PDB structures mapped to the network of E. coli metabolism (iJO1366 model [27]). The heat map indicates an increase in the number of available experimental protein structures that map to a given reaction in the pathway (grey to blue to red transitions represents 0 to more than 10 PDB structures). Subsystems such as glycolysis and TCA are highlighted by the colored grey squares and transporters by transparent rectangles with grey borders. The largest increase in coverage in subsystems involved in alanine and aspartate metabolism, glycolysis and gluconeogenesis, folate metabolism, cysteine metabolism, the citric acid cycle, arginine and proline metabolism, tRNA charging, and nitrogen metabolism