From: Low potency toxins reveal dense interaction networks in metabolism
Endpoint | Number | Correlation with Toxicity | Endpoint distribution (log molar) | Ub5 distribution | Ub6 distribution | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | Ub5 | Ub6 | mean | median | Std. dev | skew | max | min | mean | median | St. Dev | skew | max | min | mean | median | St. Dev. | skew | max | min |
Trout 24Â h | 186 | -0.230 ** | -0.337 *** | -5.73 | -5.64 | 1.39 | -0.14 | -0.99 | -10.04 | 7.58 | 7 | 1.92 | 0.01 | 11 | 2 | 8.94 | 9 | 1.91 | -0.74 | 12 | 2 |
Trout 96Â h | 181 | -0.419 *** | -0.516 *** | -5.73 | -5.78 | 1.77 | 0.76 | -0.23 | -10.88 | 7.58 | 7 | 1.94 | 0.01 | 11 | 2 | 8.94 | 9 | 1.92 | -0.76 | 12 | 2 |
Pteronarcys (24Â h) | 52 | -0.433 ** | -0.385 ** | -6.25 | -6.83 | 1.27 | 0.75 | -3.24 | -7.98 | 8.52 | 8 | 1.70 | 0.15 | 11 | 6 | 9.71 | 10 | 1.60 | -0.37 | 12 | 6 |
Pteronarcys (96Â h) | 52 | -0.456 *** | -0.369 ** | -7.08 | -7.58 | 1.44 | 0.61 | -3.71 | -9.55 | 8.44 | 8 | 1.67 | 0.22 | 11 | 6 | 9.65 | 10 | 1.58 | -0.29 | 12 | 6 |
Bluegill (24Â h) | 157 | -0.149 | -0.215 ** | -5.71 | -5.63 | 1.41 | -0.21 | -2.31 | -9.61 | 7.92 | 8 | 1.82 | 0.22 | 11 | 4 | 9.30 | 9 | 1.65 | -0.28 | 12 | 4 |
Bluegill (96Â h) | 172 | -0.216 ** | -0.276 *** | -5.88 | -5.84 | 1.48 | -0.16 | -2.31 | -10.20 | 7.85 | 8 | 1.82 | 0.23 | 11 | 4 | 9.23 | 9 | 1.70 | -0.33 | 12 | 4 |
Gammarus (24Â h) | 113 | -0.437 *** | -0.208 * | -6.17 | -6.35 | 1.46 | -0.16 | -3.52 | -10.73 | 8.19 | 8 | 1.71 | 0.43 | 11 | 6 | 9.64 | 10 | 1.46 | -0.16 | 12 | 6 |
Gammarus (96Â h) | 132 | -0.407 *** | -0.205 * | -6.56 | -6.66 | 1.63 | -0.12 | -3.20 | -10.82 | 8.14 | 8 | 1.71 | 0.46 | 11 | 6 | 9.57 | 9 | 1.47 | -0.12 | 12 | 6 |
Fathead minnow | 578 | -0.311 *** | -0.308 *** | -3.83 | -3.82 | 1.38 | -0.15 | -0.04 | -9.38 | 5.59 | 5 | 1.41 | 1.07 | 11 | 2 | 7.07 | 7 | 1.75 | 0.19 | 12 | 2 |
Rat oral | 814 | -0.441 *** | -0.372 *** | -2.40 | -2.27 | 0.91 | -0.99 | -0.43 | -6.98 | 6.57 | 6 | 1.64 | 0.40 | 11 | 2 | 8.11 | 9 | 2.14 | -0.34 | 12 | 2 |
Mouse oral | 398 | -0.199 *** | -0.191 *** | -2.56 | -2.47 | 0.82 | -1.30 | -0.65 | -6.34 | 6.96 | 7 | 1.43 | -0.02 | 11 | 2 | 8.80 | 9 | 1.86 | -0.57 | 12 | 2 |
Rat IP | 170 | -0.214 ** | -0.147 | -3.03 | -2.88 | 0.86 | -0.66 | -0.90 | -5.61 | 6.85 | 7 | 1.35 | 0.24 | 11 | 3 | 8.64 | 9 | 1.71 | -0.31 | 12 | 3 |
Mouse IP | 290 | -0.180 ** | -0.161 ** | -3.21 | -3.02 | 1.04 | -0.93 | -0.99 | -7.50 | 6.85 | 7 | 1.45 | -0.09 | 11 | 2 | 8.50 | 9 | 1.98 | -0.46 | 12 | 2 |
AMES | 163 | -0.316 *** | -0.518 *** | -4.72 | -4.25 | 1.67 | -0.51 | -1.52 | -9.88 | 6.33 | 7 | 1.33 | 0.07 | 11 | 2 | 8.40 | 9 | 2.09 | -0.49 | 12 | 2 |
CPDBAS rat | 519 | -0.198 *** | -0.191 *** | -4.18 | -4.19 | 1.42 | -0.24 | -0.47 | -9.85 | 6.36 | 6 | 1.35 | -0.09 | 11 | 2 | 8.03 | 8 | 2.08 | -0.23 | 12 | 2 |
CPDBAS mouse | 402 | -0.145 ** | -0.198 *** | -3.62 | -3.54 | 1.18 | -0.60 | -0.53 | -9.32 | 6.19 | 6 | 1.43 | -0.18 | 10 | 2 | 7.85 | 8 | 2.21 | -0.32 | 12 | 2 |
CPDBAS hamster | 44 | -0.430 ** | -0.351 * | -4.46 | -4.53 | 0.99 | 0.43 | -1.89 | -6.05 | 5.95 | 6 | 1.51 | -0.64 | 9 | 2 | 7.32 | 8 | 2.43 | -0.17 | 12 | 2 |
Drosophila | 139 | -0.397 *** | -0.337 *** | -1.43 | -1.29 | 0.94 | -0.82 | 0.23 | -4.80 | 5.82 | 6 | 1.35 | 0.17 | 10 | 2 | 7.32 | 7 | 2.07 | 0.00 | 12 | 2 |
Lemna - non-Herbicides | 149 | -0.428 *** | -0.502 *** | -4.85 | -5.12 | 1.47 | 0.85 | -0.24 | -8.20 | 7.01 | 7 | 1.50 | -0.37 | 11 | 2 | 8.68 | 9 | 1.94 | -0.87 | 12 | 2 |
Lemna - Herbicides | 174 | -0.392 *** | -0.428 *** | -6.21 | -6.08 | 1.65 | -0.19 | -2.99 | -10.23 | 8.02 | 8 | 1.63 | 0.27 | 11 | 4 | 9.56 | 9 | 1.77 | -0.02 | 12 | 4 |
Tetrahymena | 334 | -0.408 *** | -0.448 *** | -3.51 | -3.59 | 0.97 | 0.10 | -1.07 | -5.82 | 5.62 | 5.5 | 1.03 | -0.01 | 8 | 2 | 7.16 | 7 | 1.55 | -0.11 | 12 | 2 |
Chlorella | 91 | -0.578 *** | -0.738 *** | -2.86 | -3.16 | 1.47 | 0.43 | 1.06 | -6.10 | 6.15 | 6 | 1.74 | 0.86 | 11 | 2 | 7.62 | 7 | 1.77 | -0.43 | 11 | 2 |
Scenedesmus | 63 | -0.237 | -0.467 *** | -5.80 | -5.90 | 1.61 | 1.24 | 0.10 | -8.04 | 6.27 | 6 | 1.15 | 0.10 | 9 | 3 | 8.17 | 9 | 1.53 | -0.92 | 11 | 3 |
Yeast | 253 | 0.095 | -0.014 | -4.69 | -4.56 | 0.44 | -0.61 | -4.01 | -5.77 | 6.76 | 7 | 1.02 | 0.01 | 10 | 4 | 8.96 | 9 | 1.42 | -0.01 | 12 | 5 |
NCI | 768 | -0.113 ** | -0.137 *** | -5.03 | -4.67 | 1.38 | -1.19 | -2.03 | -10.02 | 7.04 | 7 | 1.07 | 0.81 | 11 | 4 | 9.14 | 9 | 1.33 | -0.20 | 12 | 5 |
HERG | 229 | -0.062 | 0.179 ** | -5.50 | -5.42 | 1.27 | -0.09 | -2.36 | -8.59 | 7.14 | 7 | 1.01 | -0.14 | 10 | 4 | 9.67 | 9 | 1.29 | -0.03 | 12 | 5 |
Oestrogenic | 131 | -0.024 | -0.342 *** | -5.62 | -5.32 | 1.78 | -0.47 | -2.52 | -9.65 | 6.16 | 6 | 0.95 | 0.49 | 10 | 4 | 8.97 | 9 | 1.24 | -0.06 | 12 | 6 |
Tadpole narcosis | 141 | -0.043 | -0.267 ** | -2.47 | -2.37 | 1.15 | -0.32 | -0.19 | -5.33 | 5.01 | 5 | 1.32 | 0.82 | 10 | 2 | 6.16 | 6 | 1.82 | 0.48 | 11 | 2 |
COX-2 | 107 | -0.069 | -0.149 | -6.36 | -6.52 | 1.51 | 0.48 | -3.00 | -8.70 | 7.72 | 8 | 0.56 | 0.36 | 10 | 7 | 9.20 | 9 | 0.68 | -0.08 | 11 | 8 |
Antihistamine | 61 | -0.097 | -0.0126 | -7.99 | -8.13 | 1.27 | 0.84 | -4.05 | -10.59 | 6.92 | 7 | 0.76 | 0.61 | 9 | 6 | 10.2 | 10 | 1.26 | -0.23 | 12 | 7 |