Fig. 5
From: Low potency toxins reveal dense interaction networks in metabolism
Correlation of UnBiological with toxicity by potency band. Correlation of Ub 5 and Ub 6 with different toxicity endpoints. For each data set, the data on a compound was binned for compounds having different EC50 or LD50 values, and the correlation of the toxicity endpoint with Ub was correlated with the toxicity values within that concentration range. Thus for Rat oral LD50 (Panel a), toxicity was binned into Log(LD50) < −4, Log(LD50) between −4 and −3, Log(LD50) between −3 and −2, and Log(Ld50) > −2, all values in molar. Correlations were calculated for each of these four data sets. Error bars are 95 % confidence limits for the correlation, based on the number of data points in each bin. For all panels: X axis = concentration bins, in log (molar). Y axis: correlation of Ub and toxicity within that data sub-set. Panels a: to f: − Rat oral toxicity, mouse oral toxicity, rat carcinogenic potential (from CPDBAS), NCI cell line cytotoxicity, Fathead minnow toxicity and tetrahymena toxicity