Fig. 6

The integrated genetic and epigenetic cellular network for investigating the cellular mechanisms of normal and HIV-infected T cells at the intermediate HIV infection stage, i.e., the integration/replication stage. The associations include those in HIV-infected cells (dotted lines), normal cells (dashed lines), and both cell types (solid lines). The bold lines indicate large genetic and epigenetic regulatory effects or genetic expression. Dysregulation of MIR139-5p, and MIRLET7i contributes to dysfunction of the immune response and viral replication via DNA hypermethylation