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Fig. 1 | BMC Systems Biology

Fig. 1

From: Constructing an integrated genetic and epigenetic cellular network for whole cellular mechanism using high-throughput next-generation sequencing data

Fig. 1

Schematic diagram of candidate integrated genetic and epigenetic cellular networks (IGECN). The candidate IGECN was constructed using omics data and database mining. The candidate IGECN mainly consisted of three sub-networks: the candidate protein-protein interaction network (PPIN) including signal transduction pathways and metabolic pathways, the candidate gene regulatory network (GRN) in which transcriptional regulation occurs, and the candidate miRNA regulatory network. The epigenetic regulation of DNA methylation was considered to influence gene transcription. Transcription factors (TFs) represent the interface between PPINs and GRNs, and genes represent the interface between GRNs, miRNA regulatory networks, PPINs, and methylation regulatory networks

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