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Table 1 Odds ratio logistic regression associations of RAAS complex SNPs with RAAS and cytochrome P450 1A2

From: Characterizing redescriptions using persistent homology to isolate genetic pathways contributing to pathogenesis

Locus DxT2D DxT2D DxHT DxHT DxHL DxHL
  cluster   cluster   cluster  
rs5065 0.93 0.94 1.01 0.99 0.96 0.96
G (0.77–1.12) (0.82–1.08) (0.88–1.16) (0.87–1.12) (0.82–1.10) (0.84–1.09)
  0.443 0.378 0.863 0.836 0.542 0.553
rs6693954 0.80 0.74 0.84 0.91 0.88 0.91
A (0.66–0.98) (0.63–0.85) (0.72–0.99) (0.79–1.05) (0.76–1.03) (0.79–1.06)
  0.029 6.22×10−5 0.0321 0.221 0.120 0.221
rs699 0.84 0.89 0.94 0.96 0.92 0.92
A (0.67–1.06) (0.75–1.06) (0.79–1.13) (0.81–1.13) (0.77–1.10) (0.78–1.09)
  0.138 0.182 0.541 0.632 0.366 0.333
rs1042713 0.93 0.94 0.99 1.01 0.98 1.03
A (0.80–1.09) (0.84–1.05) (0.88–1.12) (0.91–1.13) (0.87–1.11) (0.93–1.15)
  0.376 0.277 0.895 0.798 0.763 0.564
rs762551 1.42 1.23 1.28 1.17 0.93 0.94
C (1.19–1.69) (1.08–1.39) (1.12–1.47) (1.03–1.33) (0.81–1.07) (0.83–1.07)
  8.21×10−5 0.00203 0.000375 0.0188 0.297 0.332
rs1378942 1.33 1.19 1.27 1.22 0.97 0.99
C (1.11–1.59) (1.05–1.34) (1.11–1.46) (1.07–1.38) (0.84–1.11) (0.87–1.12)
  0.00154 0.00706 0.000672 0.00288 0.633 0.899
rs1133323 0.80 0.78 1.00 0.92 1.11 1.01
A (0.66–0.97) (0.68–0.90) (0.86–1.16) (0.80–1.06) (0.96–1.30) (0.88–1.16)
  0.0245 0.00758 0.983 0.235 0.164 0.884
rs4343 1.04 0.94 0.98 0.93 1.07 0.98
A (0.90–1.20) (0.87–1.09) (0.88–1.10) (0.84–1.04) (0.95–1.20) (0.88–1.09)
  0.618 0.646 0.785 0.200 0.273 0.698
  1. Entries show locus w/ minor allele, and the odds ratio, 95 p-value for the SNP vs. the phenotype. DxT2D cluster = DxT2D Age ≥ 60 DxHT DxCAD, DxHT cluster = Age ≥ 60 DxHT DxCAD, DxHL cluster = DxHL Male DxCAD