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Table 1 Odds ratio logistic regression associations of RAAS complex SNPs with RAAS and cytochrome P450 1A2

From: Characterizing redescriptions using persistent homology to isolate genetic pathways contributing to pathogenesis

Locus

DxT2D

DxT2D

DxHT

DxHT

DxHL

DxHL

 

cluster

 

cluster

 

cluster

 

rs5065

0.93

0.94

1.01

0.99

0.96

0.96

G

(0.77–1.12)

(0.82–1.08)

(0.88–1.16)

(0.87–1.12)

(0.82–1.10)

(0.84–1.09)

 

0.443

0.378

0.863

0.836

0.542

0.553

rs6693954

0.80

0.74

0.84

0.91

0.88

0.91

A

(0.66–0.98)

(0.63–0.85)

(0.72–0.99)

(0.79–1.05)

(0.76–1.03)

(0.79–1.06)

 

0.029

6.22×10−5

0.0321

0.221

0.120

0.221

rs699

0.84

0.89

0.94

0.96

0.92

0.92

A

(0.67–1.06)

(0.75–1.06)

(0.79–1.13)

(0.81–1.13)

(0.77–1.10)

(0.78–1.09)

 

0.138

0.182

0.541

0.632

0.366

0.333

rs1042713

0.93

0.94

0.99

1.01

0.98

1.03

A

(0.80–1.09)

(0.84–1.05)

(0.88–1.12)

(0.91–1.13)

(0.87–1.11)

(0.93–1.15)

 

0.376

0.277

0.895

0.798

0.763

0.564

rs762551

1.42

1.23

1.28

1.17

0.93

0.94

C

(1.19–1.69)

(1.08–1.39)

(1.12–1.47)

(1.03–1.33)

(0.81–1.07)

(0.83–1.07)

 

8.21×10−5

0.00203

0.000375

0.0188

0.297

0.332

rs1378942

1.33

1.19

1.27

1.22

0.97

0.99

C

(1.11–1.59)

(1.05–1.34)

(1.11–1.46)

(1.07–1.38)

(0.84–1.11)

(0.87–1.12)

 

0.00154

0.00706

0.000672

0.00288

0.633

0.899

rs1133323

0.80

0.78

1.00

0.92

1.11

1.01

A

(0.66–0.97)

(0.68–0.90)

(0.86–1.16)

(0.80–1.06)

(0.96–1.30)

(0.88–1.16)

 

0.0245

0.00758

0.983

0.235

0.164

0.884

rs4343

1.04

0.94

0.98

0.93

1.07

0.98

A

(0.90–1.20)

(0.87–1.09)

(0.88–1.10)

(0.84–1.04)

(0.95–1.20)

(0.88–1.09)

 

0.618

0.646

0.785

0.200

0.273

0.698

  1. Entries show locus w/ minor allele, and the odds ratio, 95 p-value for the SNP vs. the phenotype. DxT2D cluster = DxT2D Age ≥ 60 DxHT DxCAD, DxHT cluster = Age ≥ 60 DxHT DxCAD, DxHL cluster = DxHL Male DxCAD