Skip to main content
Fig. 2 | BMC Systems Biology

Fig. 2

From: c-Myc and viral cofactor Kaposin B co-operate to elicit angiogenesis through modulating miRNome traits of endothelial cells

Fig. 2

c-Myc cooperates with Kaposin B to regulate cellular known miRNAs. a smRNA-Seq revealed differentially expressed miRNAs between Kaposin B(+) and HUVECs (≥1.5 folds, left), and between Kaposin B(+)c-Myc(+) and HUVECs (≥1.5 folds, right). b Venn diagrams summarizing significant overlap between c-Myc and Kaposin B known miRNAs signature. (upper panel) up-regulated miRNAs; (lower panel) down-regulated miRNAs. c Gene Set Enrichment Analysis (GSEA) verified the significant overlap between c-Myc and Kaposin B miRNAs signature. d RT-qPCR detected various known miRNAs expression. Mean expression levels of the target miRNAs are compared with the U6 control (n = 3). *: P < .05. e RT-qPCR detected miR-221/miR-222 expression in Kaposin B(+) and Kaposin B(+)c-Myc(+) cells. f The biological pathway of genes which were targeted by the Kaposin B(+)c-Myc(+) induced/reduced miRNAs. The P value were marked on the figure

Back to article page