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Table 4 Summary of predicted disease effects on liver regeneration

From: Systems analysis of non-parenchymal cell modulation of liver repair across multiple regeneration modes

Disease Model

Mass Recovery

Priming

Replication

IL-6 Signaling

GF

ECM

(1) Non-alcoholic Steatohepatitis

Suppressed

Low

Low

Low

High

High

(2) Alcoholic Steatohepatitis

Suppressed

Sustained

Low

Sustained

Low

High

(3) Toxin-induced Cirrhosis

Suppressed

High

Low

High

Low

High

(4) Allotaxin-induced Diabetes

Delayed

High

Delayed & low

Sustained

Low

Low